This guide contains information about places where you can stop for the night when driving from Knoxville, Tennessee to Myrtle Beach, South Carolina. Total distance for the trip is around 411 miles with a driving time of approximately 6 hours 22 mins. Cities and towns with hotels that are on the fastest route between Knoxville and Myrtle Beach are listed below. (Driving times are approximate and will vary with traffic and weather conditions.)